Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

492
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
492
Antianginal Drugs: Calcium Channel Blockers and Ranolazine01:25

Antianginal Drugs: Calcium Channel Blockers and Ranolazine

464
Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
464
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

147
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
147
Vascular Spasm01:16

Vascular Spasm

1.3K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
1.3K
Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

Antihypertensive Drugs: Action of Calcium Channel Blockers

473
Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
473

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Four new species of <i>Microdochium</i> (<i>Microdochiaceae</i>, <i>Xylariales</i>) based on morphology and multilocus phylogeny from Hainan, China.

MycoKeys·2026
Same author

A review of organoid-immune co-culture platforms to model the immune microenvironment of hepatocellular carcinoma and guide immunotherapy.

Journal of translational medicine·2026
Same author

All-in-One Fluorescent Probe: Enabling Simultaneous Tracking of Multiple Dynamic Organellar Perturbations during Ferroptosis.

Analytical chemistry·2026
Same author

A state-of-the-art review on chairside CAD/CAM ceramic materials in restorative dentistry.

Biomaterials advances·2026
Same author

CRP Cutoff Value in East Asians With Coronary Heart Disease: A Systematic Review and Meta-Analysis.

JACC. Asia·2026
Same author

Astrocytic Netrin-1 modulates stress-induced anxiety susceptibility in mice through ADAM17-mediated TNFα shedding.

Journal of neuroinflammation·2026
Same journal

Wartime Healers: The Collective Awakening and National Mission of PUMC Medical Community during the Chinese People's War of Resistance against Japanese Aggression.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih·2026
Same journal

Endometrial Carcinoma Arising in Adenomyosis in the Myometrium with Uninvolved Endometrium: A Case Report.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih·2026
Same journal

Emergency Management of Crushing Perineal Avulsion with Complete Urethral Disruption: A Case Report.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih·2026
Same journal

Good Data Governance Practice and a Grading Initiative for Life Sciences Data.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih·2026
Same journal

Time-Dependent Neuroprotection and Precision Interventions in Acute Ischemic Stroke in the Reperfusion Era.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih·2026
Same journal

Teaching Neuraxial Ultrasonography with a Virtual Reality Simulator of Spine: A Randomized Controlled Study.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2025

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

1.6K

Vascular Calcification: Where is the Cure?

Wen-Wen Liu1, Mei-Lin Liu2

  • 1Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.

Chinese Medical Sciences Journal = Chung-Kuo I Hsueh K'O Hsueh Tsa Chih
|September 4, 2024
PubMed
Summary
This summary is machine-generated.

Vascular calcification (VC) increases with age, linked to poor health outcomes. Current treatments for VC lack clinical effectiveness, highlighting the need for novel therapeutic strategies.

Keywords:
clinicalnovel findingspathophysiologytherapeutic strategiesvascular calcification

More Related Videos

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.5K
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

1.9K

Related Experiment Videos

Last Updated: Jun 14, 2025

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

1.6K
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.5K
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

1.9K

Area of Science:

  • Biomedical research
  • Cardiovascular science
  • Aging research

Background:

  • Vascular calcification (VC) incidence rises with aging.
  • VC is associated with increased cardiovascular events and mortality.
  • Existing interventions for VC have not demonstrated clinical effectiveness in reversal or cure.

Purpose of the Study:

  • To review novel perspectives on vascular calcification interventions.
  • To provide a reference for clinical decision-making regarding VC treatment.

Main Methods:

  • Literature review of recent advancements in VC research.
  • Analysis of emerging therapeutic targets and strategies for VC.

Main Results:

  • Current interventions for VC show limited success in clinical practice.
  • Several novel approaches targeting VC pathogenesis are under investigation.

Conclusions:

  • There is a critical need for effective treatments to reverse or cure vascular calcification.
  • This review synthesizes new insights to guide future clinical strategies for managing VC.