Cardiovascular death risk in patients with solid tumors: a population-based study in the United States
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View abstract on PubMed
Summary
This summary is machine-generated.Patients with solid tumors face a higher risk of cardiovascular disease (CVD) death, which is a significant cause of non-cancer mortality. Early screening and risk management are crucial for preventing CVD deaths in cancer patients.
Area Of Science
- Oncology
- Cardiology
- Epidemiology
Background
- Limited data exists on cardiovascular disease (CVD)-specific mortality in solid tumors.
- Previous research focused on hematological cancers and specific tumor sites.
Purpose Of The Study
- To systematically analyze the distribution, risk, and trends of CVD-specific death in patients with solid tumors.
- To evaluate the impact of solid tumors on cardiovascular mortality.
Main Methods
- Utilized the Surveillance, Epidemiology and End Results (SEER) program data for 2,679,293 patients diagnosed with solid tumors (1975-2019).
- Calculated standardized mortality ratios (SMRs) and absolute excess risks (AERs) for CVD-specific death.
- Employed competing risk regression and restricted cubic spline analyses to assess risk and age-related trends.
Main Results
- CVD-specific death comprised 48.95% of non-cancer deaths in solid tumor patients.
- Patients with solid tumors showed significantly higher SMR and AER for CVD, heart disease, and cerebrovascular disease compared to the general population.
- A decreasing trend in SMR was observed over time post-diagnosis, with a nonlinear age-CVD death relationship.
Conclusions
- Cardiovascular disease is a major cause of non-cancer mortality in solid tumor patients.
- Solid tumor patients have an elevated risk of CVD-specific death, necessitating proactive management.
- Integrating CVD screening and risk management into cancer care may reduce CVD mortality.
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