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Related Concept Videos

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Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Hpv Infection Patterns And Viral Load Distribution: Implication On Cervical Cancer Prevention In Western Kenya.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Hpv Infection Patterns And Viral Load Distribution: Implication On Cervical Cancer Prevention In Western Kenya.

Related Experiment Video

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HPV infection patterns and viral load distribution: implication on cervical cancer prevention in Western Kenya.

Ivy Akinyi1, Ogol Japheth Ouma1, Sylvester Ogutu1

  • 1School of Health Sciences, Jaramogi Oginga Odinga University of Science and Technology, Bondo, Kenya.

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
|September 4, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Human papillomavirus (HPV) coinfection is common, but its clinical impact is debated. This study in Kenya found HPV 52 as the most prevalent strain and identified specific genotype preferences in coinfections, informing vaccination strategies.

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Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Human papillomavirus (HPV) coinfection is globally prevalent, yet its clinical significance versus single infections is debated.
  • The epidemiology of HPV genotype combinations in coinfections is understudied, particularly in Kenya.

Purpose of the Study:

  • To investigate the prevalence and patterns of HPV coinfection among women in Kenya.
  • To compare viral loads between HPV mono-infection and coinfection.
  • To inform HPV vaccination strategies based on genotype distribution and coinfection tendencies.

Main Methods:

  • A cross-sectional survey of 434 women aged 16-68 years in Kenya.
  • Data collection included demographic and sexual behavior questionnaires.
  • Cervical specimens were analyzed for HPV genotypes and viral load using the RIATOL assay.

Main Results:

  • HPV 52 was the most frequently detected HPV strain in the population.
  • Mono-infection accounted for 58.52% of HPV cases.
  • HPV 16 showed similar prevalence in mono-infection (52.17%) and coinfection (47.83%).
  • HPV 33 and HPV 45 demonstrated a significant preference for coinfection with each other.
  • Mean HPV viral load was higher in coinfected women, but not statistically significant (P=0.113).

Conclusions:

  • HPV 52 prevalence supports the utility of the nonavalent HPV vaccine.
  • The persistent prevalence of HPV 16 mono-infection highlights the ongoing relevance of the bivalent vaccine in resource-limited settings.
  • The observed coinfection preference between HPV 33 and 45 warrants further investigation.
  • HPV vaccination and education on safe sexual practices are crucial for reducing HPV coinfection.