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Updated: Jun 14, 2025
Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
Published on: January 5, 2016
ADVANCEMENT IN ALPHA-SYNUCLEIN PROTEOMICS: EXPLORING ANALYTICAL TECHNIQUES AND THEIR CLINICAL IMPLICATIONS IN
S Palanisamy1, P Subramani2, P Narasimman2
11R&D Laboratory, Department of Chemistry, Excel Engineering College (Autonomous), Namakkal - 637 303, Tamil Nadu, India; 2CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, No-457 Zhongshan Road, Dalian - 116 023, P.R. China.
Abstract:
Parkinson's disease (PD) is a prevalent neurodegenerative disorder, affecting around 500,000 to 1 million Americans, with a significant portion diagnosed before age 50. Despite advances in treatments such as dopamine replacement therapy and deep brain stimulation, no therapies currently exist to halt or slow disease progression in advanced stages. Research is increasingly focused on identifying early biomarkers for PD to enable earlier intervention. Alpha-synuclein (α-Syn), a key protein implicated in PD pathology, is studied using various proteomics techniques like mass spectrometry, gel electrophoresis, and chromatography, to understand its role and alterations in PD. These techniques help in extracting, analyzing, and characterizing α-Syn from brain samples, providing insights into disease mechanisms and potential diagnostic and therapeutic applications.
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