Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

4.4K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.4K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

1.7K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.7K
Introduction to Electrolytes01:33

Introduction to Electrolytes

10.1K
In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
10.1K
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

196
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
196
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuropeptide Y and tuberoinfundibular dopamine activities are altered during lactation: role of prolactin.

Endocrinology·1999
Same author

Characteristics of delayed excretion of flavonoids in human urine after administration of Shosaiko-to, a herbal medicine.

Biological & pharmaceutical bulletin·1999
Same author

A long terminal repeat of the human endogenous retrovirus ERV-9 is located in the 5' boundary area of the human beta-globin locus control region.

Genomics·1999
Same author

Evaluation of a mucoadhesive buccal patch for delivery of peptides: in vitro screening of bioadhesion.

Drug development and industrial pharmacy·1999
Same author

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

Oncogene·1999
Same author

Cell-killing by paclitaxel in a metastatic murine melanoma cell line is mediated by extensive telomere erosion with no decrease in telomerase activity.

Oncology reports·1998

Related Experiment Video

Updated: Jun 14, 2025

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability
06:34

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

Published on: April 28, 2022

4.6K

SERUM CALCIUM WAS NEGATIVELY ASSOCIATED WITH SERUM IRON AMONG GENERAL POPULATION: FINDINGS FROM A CROSS-SECTION

Y Jin1, Z Luo1, H Su2

  • 11Department of Clinical Laboratory, Taizhou Central Hospital (Taizhou University Hospital), Taizhou University, Jiaojiang 318000, Zhejiang, China.

Georgian Medical News
|September 4, 2024
PubMed
Summary
This summary is machine-generated.

Serum calcium levels are negatively correlated with serum iron levels in the general population. This suggests that higher calcium may help regulate iron metabolism, warranting further investigation into calcium supplementation strategies.

More Related Videos

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

736
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

1.9K

Related Experiment Videos

Last Updated: Jun 14, 2025

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability
06:34

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

Published on: April 28, 2022

4.6K
Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

736
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

1.9K

Area of Science:

  • Biochemistry
  • Metabolic Diseases
  • Nutritional Science

Background:

  • Ferroptosis, a form of regulated cell death, is linked to various diseases.
  • Disruptions in iron homeostasis are a key factor in ferroptosis.
  • Vitamin D's potential role in regulating ferroptosis via calcium and iron metabolism is hypothesized but not fully understood.

Purpose of the Study:

  • To investigate the relationship between serum calcium and serum iron levels.
  • To explore potential links between calcium, iron, and ferroptosis regulation.
  • To examine this association in the general population of Taizhou, China.

Main Methods:

  • A cross-sectional study design was employed.
  • Serum calcium and serum iron levels were measured.
  • Pearson's correlation analysis was used to assess the association.

Main Results:

  • Serum iron levels showed a negative correlation with serum calcium levels.
  • Serum iron levels were also negatively correlated with age.
  • This negative correlation between serum iron and calcium persisted after controlling for age, sex, and marital status.

Conclusions:

  • Elevated serum calcium levels may represent a strategy for modulating iron metabolism homeostasis.
  • Further research is needed to determine if calcium supplementation can effectively lower serum iron in individuals with hypocalcemia.
  • Understanding the calcium-iron-ferroptosis axis could offer new therapeutic avenues.