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Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Enzyme-Catalyzed Regioselective Synthesis of 4-Hetero-Functionalized 1,5-Disubstituted 1,2,3-Triazoles
Navaneet Kumar1,2, Atul Kumar1,3
1Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
Abstract:
Enzyme-catalyzed novel protocols for the regioselective construction of fully substituted 1,2,3-triazoles by employing 2-azido-1,3,5-triazine (ADT) as a 1,3-dipole for the cycloaddition reaction with the activated alkene in an aqueous medium have been developed. Various 4-heterosubstituted-1,2,3-triazoles were readily assembled in good to excellent yields with high regioselectivity. This reaction also features wide substrate scope, strong functional group tolerance, gram-scale synthesis, and an environmentally friendly process.
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