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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Tumor-associated Carbohydrate Antigen 19-9 (ca 19-9), A Promising Target For Antibody-based Detection, Diagnosis, And Immunotherapy Of Cancer.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Tumor-associated Carbohydrate Antigen 19-9 (ca 19-9), A Promising Target For Antibody-based Detection, Diagnosis, And Immunotherapy Of Cancer.

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Tumor-Associated Carbohydrate Antigen 19-9 (CA 19-9), a Promising Target for Antibody-Based Detection, Diagnosis, and Immunotherapy of Cancer.

Athar Nakisa1,2, Lorenzo F Sempere3, Xi Chen4

  • 1Department of Chemistry, Michigan State University, East Lansing, Michigan, 48824, United States.

Chemmedchem
|September 4, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Carbohydrate antigen 19-9 (CA 19-9), a marker overexpressed in cancers like pancreatic ductal adenocarcinoma, plays key roles in tumor progression. This review explores CA 19-9

Keywords:
CA 19-9antibodiescancersynthesis

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Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • Carbohydrate antigen 19-9 (CA 19-9), also known as sialyl Lewis A, is a tetrasaccharide overexpressed on various cancer cells.
  • Elevated CA 19-9 levels are observed in patients with malignancies, particularly pancreatic ductal adenocarcinoma.
  • CA 19-9 is implicated in cancer progression, including metastasis, cell proliferation, and immune suppression.

Purpose of the Study:

  • To review the synthesis of the CA 19-9 antigen.
  • To discuss the development and applications of anti-CA 19-9 antibodies.
  • To explore CA 19-9's potential in cancer diagnosis, prognosis, and therapy.

Main Methods:

  • Review of existing literature on CA 19-9.
  • Discussion of antibody elicitation through vaccination.
vaccines
  • Analysis of monoclonal antibody development.
  • Examination of applications in imaging and therapeutics.

    • Main Results:

    • CA 19-9's role in facilitating cancer cell extravasation and metastasis.
    • CA 19-9's involvement in cancer cell proliferation and immune system suppression.
    • Development of anti-CA 19-9 antibodies for diagnostic and therapeutic purposes.

    Conclusions:

    • CA 19-9 is a significant biomarker and therapeutic target in oncology.
    • Anti-CA 19-9 antibodies show promise as imaging agents and therapeutics.
    • Further research into CA 19-9 applications may improve cancer patient outcomes.