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Mitochondrial Influence on Performance Fatigability: Considering Sex Variability.

Gaia Giuriato, Chiara Barbi¹, Fabio Giuseppe Laginestra

¹Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, ITALY.

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|September 4, 2024

Summary

This summary is machine-generated.

Females exhibit greater fatigue resistance during dynamic leg exercises compared to males, attributed to superior mitochondrial efficiency and reduced reliance on specific metabolic pathways.

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Area of Science:

Exercise Physiology
Muscle Metabolism
Sex Differences in Performance

Background:

Existing research suggests females have higher fatigue resistance during isometric contractions.
However, sex differences in performance fatigability (PF) during dynamic single-limb exercises, considering muscle metabolism and cardiovascular responses, are not well understood.

Purpose of the Study:

To investigate how sex influences the relationship between muscle oxidative characteristics and the development of performance fatigability during dynamic single-leg exercise.
To explore sex-specific differences in neuromuscular and metabolic responses during fatiguing dynamic contractions.

Main Methods:

Twenty-four healthy young adults (12 males, 12 females) completed a single-leg knee extension task to exhaustion.
Neuromuscular function was assessed before and after exercise using magnetic and peripheral stimulations.
Muscle biopsies analyzed mitochondrial respiration and fiber type composition.

Main Results:

Both sexes performed similar total work and reached exhaustion at similar time points.
Females showed significantly less decline in maximal voluntary contraction and resting twitch force post-exercise.
Males exhibited lower mitochondrial net oxidative capacity and higher reliance on Complex II for maximal respiration, which correlated with greater force decline.

Conclusions:

Females demonstrate superior resistance to performance fatigability during dynamic single-leg exercise.
This enhanced fatigue resistance in females is likely linked to their greater mitochondrial efficiency and lower dependence on Complex II activity.
Sex differences in muscle metabolic characteristics play a crucial role in fatigability during dynamic contractions.