Related Experiment Video
Updated: Jun 14, 2025

Nanomanipulation of Single RNA Molecules by Optical Tweezers
Published on: August 20, 2014
Cryo-EM: A window into the dynamic world of RNA molecules
Xiaojing Zhang1, Shanshan Li1, Kaiming Zhang1
1Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
Abstract:
RNAs are critical for complex cellular functions, characterized by their structural versatility and ability to undergo conformational transitions in response to cellular cues. The elusive structures of RNAs are being unraveled with unprecedented clarity, thanks to the technological advancements in structural biology, including nuclear magnetic resonance (NMR), X-ray crystallography, cryo-electron microscopy (cryo-EM) etc. This review focuses on examining the revolutionary impact of cryo-EM on our comprehension of RNA structural dynamics, underscoring the technique's contributions to structural biology and envisioning the future trajectory of this rapidly evolving field.
More Related Videos
09:25Do's and Don'ts of Cryo-electron Microscopy: A Primer on Sample Preparation and High Quality Data Collection for Macromolecular 3D Reconstruction
Published on: January 9, 2015
12:26Optical Tweezers to Study RNA-Protein Interactions in Translation Regulation
Published on: February 12, 2022
Related Concept Videos
Cryo-electron Microscopy
RNA Stability
Nucleic Acids
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
Protein Dynamics in Living Cells
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
Nucleic Acid Structure
DNA Structure
DNA...