The miRNA Landscape in Crohn's disease: Implications for novel therapeutic approaches and interactions with Existing

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Updated: Jun 14, 2025

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
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Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Published on: December 15, 2017

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Hebatallah Ahmed Mohamed Moustafa1, Elsayed G E Elsakka2, Ahmed I Abulsoud3

  • 1Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.

Experimental Cell Research
|September 5, 2024
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in inflammatory diseases like Crohn's disease (CD). Research highlights their diagnostic and therapeutic potential for CD-related inflammation and fibrosis, moving miRNA-based treatments closer to clinical application.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation.
  • Inflammatory diseases, such as Crohn's disease (CD), are complex conditions with significant unmet needs.
  • Emerging evidence implicates miRNAs in the pathogenesis of CD, including inflammation and fibrosis.

Purpose of the Study:

  • To review current advancements in understanding the role of miRNAs in Crohn's disease.
  • To explore the diagnostic and therapeutic potential of miRNAs in CD.
  • To identify potential miRNA targets for treating CD-related inflammation and fibrosis.

Main Methods:

  • This study is an extensive narrative review.
  • It synthesizes findings from in vitro and in vivo investigations.
  • The review focuses on existing literature regarding miRNA involvement in CD.

Main Results:

  • miRNAs are implicated in the mechanisms of CD aggravation and fibrogenesis.
  • miRNAs show promise as biomarkers for inflammation and fibrosis in CD.
  • miRNA-based therapies, including mimicry and inhibition, are being investigated for CD treatment.

Conclusions:

  • Identifying specific miRNAs and their targets can enhance understanding of CD pathophysiology.
  • miRNA-based approaches offer potential for novel diagnostic and therapeutic strategies in CD.
  • Further research is needed, but miRNA-based therapy is progressing towards clinical practice for managing CD.
Keywords:
Crohn's diseaseDiagnosisFibrosisInflammationTherapymiRNA

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