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Identifying mesonephric-like adenocarcinoma of the endometrium by combining SOX17 and PAX8 immunohistochemistry

  • 0Department of Pathology, The Ohio State University, Columbus, OH, USA.
Histopathology +

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September 5, 2024

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September 5, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study identifies SOX17 as a key marker for diagnosing mesonephric-like adenocarcinoma (MLA). Combining SOX17 and PAX8 immunohistochemistry (IHC) can help differentiate MLA from other endometrial carcinomas.

Area Of Science

  • Gynecologic Pathology
  • Oncology
  • Immunohistochemistry

Background

  • Mesonephric-like adenocarcinoma (MLA) is a rare endometrial and ovarian carcinoma with distinct features.
  • SOX17 is a recently identified marker for endometrial and ovarian carcinomas.

Purpose Of The Study

  • To investigate SOX17 expression in MLA.
  • To differentiate MLA from other endometrial carcinomas using SOX17 and other immunohistochemical (IHC) markers.

Main Methods

  • Seventeen endometrial/ovarian MLA cases were analyzed using multiple IHCs.
  • SOX17, PAX8, and ER expression was evaluated on tissue microarrays (TMAs) of 652 endometrial carcinomas.
  • A combined SOX17 and PAX8 IHC approach was used to screen TMAs.

Main Results

  • All MLAs showed strong PAX8 positivity and negative ER staining.
  • MLAs exhibited negative or focal weak/moderate SOX17 staining.
  • Combined SOX17 and PAX8 IHC identified 14 potential MLA cases from the TMA cohort, with seven confirmed as MLA.

Conclusions

  • SOX17 and PAX8 immunohistochemistry aids in diagnosing MLA.
  • Strong positive PAX8 and negative SOX17 staining suggests MLA.

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