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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

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Updated: Jun 14, 2025

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Current immunotherapy techniques in meningioma.

Alexandra J White¹, Maya Harary¹, Joshua Casaos¹

¹Department of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA.

Expert Review of Anticancer Therapy

|September 5, 2024

Summary

This summary is machine-generated.

Meningioma immunotherapy shows promise due to the tumor's location outside the blood-brain barrier. Further research into meningioma immunology is crucial for developing effective immunotherapy treatments.

Keywords:

Meninges brain tumor checkpoint inhibitor dura immunology immunotherapy neuroimmunology targeted therapy

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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Area of Science:

Neuro-oncology
Immunology
Brain Tumor Research

Background:

Meningiomas are the most common primary brain tumors.
Limited treatment options exist for recurrent or aggressive meningiomas.
Meningiomas' location outside the blood-brain barrier suggests unique immunotherapy potential.

Purpose of the Study:

To review the current understanding of meningioma immunology and immunotherapy.
To summarize existing literature on immune cell infiltration and signaling in meningioma.
To explore current and future immunotherapeutic approaches for meningioma.

Main Methods:

Comprehensive literature review of MEDLINE (1/1/1990-6/1/2024).
Analysis of immune cell infiltration, immune signaling, and immunogenicity in meningioma.
Evaluation of potential immunotherapeutic strategies.

Main Results:

Meningioma immunotherapy is in its nascent stages with no current guideline inclusion.
Significant heterogeneity exists in immune cell infiltration, immunogenicity, and immune escape.
Potential immunotherapeutic strategies include immune checkpoint inhibitors, CAR-T cell therapy, and tumor vaccines.

Conclusions:

Understanding meningioma immunology is key to advancing immunotherapy.
Tumor classification and patient selection are vital for successful immunotherapy.
Further research can unlock the potential of immunotherapy for meningioma treatment.