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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
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Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications.

Monika Dobrzyńska-Mizera1, Jagan Mohan Dodda2, Xiaohua Liu3

  • 1Institute of Materials Technology, Polymer Division, Poznan University of Technology, Poznan, Poland.

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|September 5, 2024
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Summary

This review covers resorbable polymeric biomaterials, their design, and applications in tissue engineering and medical devices. It highlights fabrication methods, imaging evaluations, and regulatory challenges for clinical translation.

Keywords:
clinical challengesdrug deliveryimplantsmedical imagingpolymer matricesresorbable biomaterialstissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Engineering
  • Medical Device Development

Background:

  • Resorbable polymeric biomaterials are crucial for various medical applications due to their temporary nature.
  • Advances in material science have enabled the development of sophisticated resorbable polymers with tailored properties.
  • Understanding the fabrication, resorption, and performance of these materials is key for clinical success.

Purpose of the Study:

  • To critically review recent advances in resorbable polymeric-based biomaterials.
  • To discuss engineering approaches for fabricating scaffolds for diverse biomedical applications.
  • To highlight evaluation methods and regulatory considerations for clinical translation.

Main Methods:

  • Comprehensive literature review of resorbable polymeric biomaterials.
  • Analysis of fabrication techniques for polymeric scaffolds.
  • Examination of medical imaging studies for scaffold evaluation.

Main Results:

  • Detailed overview of resorbable polymer types, geometrical forms, and resorption mechanisms.
  • Discussion of applications in tissue engineering, drug delivery, and cardiovascular, dental, and surgical fields.
  • Insights from medical imaging techniques like cardiac computed tomography for structural evaluation.

Conclusions:

  • Resorbable polymeric biomaterials offer significant potential across numerous medical fields.
  • Advanced fabrication and evaluation methods are essential for meeting stringent medical requirements.
  • Addressing regulatory challenges is critical for translating research into clinical and marketable products.