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Updated: Jun 14, 2025
Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophil extracellular traps in respiratory ailment: Pathogenic mechanisms and clinical translation
Shun-Yu Wu1, Bo-Yu Cai1, Tian-Yu Wang1
1Department of Otolaryngology The Second Affiliated Hospital of the Naval Military Medical University (Shanghai Changzheng Hospital) Shanghai China.
Background:
Eosinophilic extracellular traps (EETs) are reticular complexes comprising deoxyribonucleic-Acid (DNA) fibers and granule proteins.
Aims:
EETs play a crucial role in antimicrobial host responses and are pathogenic when overproduced or under degraded. EETs created by eosinophils appear to enable vital immune responses against extra-cellular pathogens, nevertheless, trap overproduction is evident in pathology.
Materials & Methods:
As considerably research is performed, new data affirmed that EETs can alter the outcome of respiratory ailment.
Results:
We probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic, unresolved inflammation.
Discussion:
Whether EETs can be used as a prospective brand-new target for the diagnosis, treatment and prognosis of respiratory ailments is a scientific theme worth studying.
Conclusion:
We probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic, unresolved inflammation.
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