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Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
The Association Between Surgical Site Infection And Prognosis Of T4 Colorectal Cancer.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
The Association Between Surgical Site Infection And Prognosis Of T4 Colorectal Cancer.

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Published on: September 27, 2024

The Association Between Surgical Site Infection and Prognosis of T4 Colorectal Cancer.

Takuya Koike¹, Masaya Mukai¹, Kyoko Kishima¹

¹Department of Gastroenterological Surgery, Tokai University Hachioji Hospital, Hachioji, JPN.

|September 5, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Surgical site infection (SSI) in patients with T4 colorectal cancer significantly worsens prognosis and increases recurrence risk. Incisional/deep SSI poses a greater risk, necessitating closer follow-up and tailored treatment.

Keywords:

overall survival prognosis relapse-free survival surgical site infection

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Area of Science:

Oncology
Surgical Oncology
Cancer Prognostics

Background:

T4 colorectal cancer presents a poor prognosis with undefined prognostic factors.
Surgical site infection (SSI) is a potential risk factor for colorectal cancer recurrence.

Purpose of the Study:

To evaluate the relationship between SSI occurrence and the prognosis of T4 colorectal cancer.
To assess the prognostic impact of SSI site on T4 colorectal cancer outcomes.

Main Methods:

A retrospective case-control study of 100 T4 colorectal cancer patients undergoing radical surgery.
Comparison of 5-year relapse-free survival (RFS) and overall survival (OS) between patients with and without SSI.
Analysis of SSI site (incisional/deep vs. organ/space) and its effect on prognosis.

t4 colorectal cancer

Main Results:

Patients with SSI (n=27) showed significantly poorer 5-year RFS (22.2%) and OS (38.4%) compared to those without SSI (n=73) (RFS 55.1%, OS 67.0%).
SSI occurrence was associated with a 2.224-fold increased risk of recurrence and a 2.366-fold increased risk of mortality.
Incisional/deep SSI was linked to a significantly worse prognosis than organ/space SSI.

Conclusions:

SSI occurrence is a high-risk factor for recurrence in T4 colorectal cancer.
SSI may serve as a significant prognostic factor in this patient population.
Patients with SSI require intensified postoperative surveillance and potentially adjuvant chemotherapy.