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Updated: Jun 14, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Circulating cell adhesion molecules in systemic sclerosis: a systematic review and meta-analysis.
Arduino A Mangoni1,2, Angelo Zinellu3
1Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, SA, Adelaide, Australia.
Systemic sclerosis patients show elevated levels of specific cell adhesion molecules, including ICAM-1, VCAM-1, PECAM-1, E-selectin, and P-selectin. These molecules may serve as valuable biomarkers for assessing cardiovascular risk in SSc.
Area of Science:
- Cardiovascular Research
- Rheumatology
- Biomarker Discovery
Background:
- Patients with systemic sclerosis (SSc) face heightened risks of endothelial dysfunction, atherosclerosis, and cardiovascular events.
- Identifying reliable biomarkers for endothelial dysfunction and atherogenesis is crucial for early cardiovascular risk management in SSc.
Conclusions:
- Circulating ICAM-1, VCAM-1, PECAM-1, E-selectin, and P-selectin show potential as biomarkers for endothelial dysfunction and atherogenesis in SSc.
- These biomarkers may aid in the cardiovascular risk assessment of patients with systemic sclerosis.
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