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Area of Science:

  • Medical Informatics
  • Health Data Management

Background:

  • The German Medical Informatics Initiative (MII) aims to support multi-site research projects.
  • Data Integration Centers (DICs) at German university medical centers provide patient data via FHIR, adhering to the MII core data set (CDS).
  • Data protection regulations favor decentralized data processing and exchange of aggregated results.

Purpose of the Study:

  • To develop and implement a software architecture for decentralized processing and analysis of medical data.
  • To address the requirements of the MII use case INTERPOLAR.

Main Methods:

  • A software architecture was designed using 3LGM2 and implemented.
  • A CDS tool chain was created with software components for decentralized processing based on the MII CDS.
  • The tool chain uses a local FHIR endpoint, transfers data to an SQL database, and employs a DataProcessor component for calculations.

Main Results:

  • The CDS tool chain enables decentralized processing of medical data from local FHIR endpoints into an SQL database.
  • A frontend module (REDCap) allows for displaying, verifying, and evaluating processed data and calculated results.
  • Feedback and results are stored in the database for future analysis and data sharing.

Conclusions:

  • The developed CDS tool chain leverages SQL databases for flexible and direct data processing using established methods.
  • The modular design allows for adaptation to other projects, with plans for future enhancements like pseudonymization and data sharing.