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Associations of Rest-Activity Rhythm Disturbances With Stroke Risk and Poststroke Adverse Outcomes.

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Disrupted 24-hour rest-activity rhythms are linked to increased stroke risk. A suppressed or fragmented rhythm may also predict worse outcomes after a stroke.

Keywords:
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Area of Science:

  • Chronobiology
  • Neurology
  • Public Health

Background:

  • Circadian clocks influence many biological processes and exhibit ~24-hour rhythms.
  • The relationship between disruptions in these rhythms and stroke risk is not well understood.
  • This study investigates the association between 24-hour rest-activity patterns and stroke risk.

Purpose of the Study:

  • To evaluate the association between 24-hour rest-activity rhythms and stroke risk.
  • To determine if rhythm disruptions predict major adverse outcomes following a stroke.

Main Methods:

  • Utilized UK Biobank data from ~100,000 participants (aged 44-79).
  • Assessed rest-activity rhythms using actigraphy over 6-7 days.
  • Employed Cox proportional hazard models for incident stroke and poststroke adverse outcomes over a 5-year median follow-up.

Main Results:

  • A suppressed relative amplitude (lowest quartile) was associated with a 61% increased stroke risk (HR, 1.61).
  • Later midpoint timing of the most active 10-hour period also correlated with higher stroke risk (HR, 1.26).
  • Fragmented rhythms (higher intradaily variability) were linked to increased stroke risk (HR, 1.26) and poststroke adverse outcomes (HR, 2.02).

Conclusions:

  • A suppressed 24-hour rest-activity rhythm appears to be a significant risk factor for stroke.
  • Rhythm fragmentation may serve as an early indicator of major adverse outcomes post-stroke.
  • These findings highlight the importance of circadian health in cardiovascular disease prevention.