Intracamerally applied prostacyclin raises the intraocular pressure in the rabbit

The effects of prostacyclin (PGI2) upon intraocular pressure and pupil size were examined in anaesthetized rabbits. Intracamerally applied PGI2 within the dosage range of 0.1 to 1.0/microgram led to an increase of the intraocular pressure (IOP) measured directly and continuously, and to a miosis. 6-oxo-PGF1 alpha, the product of hydrolysis of prostacyclin did not influence IOP or reaction of the pupil. Topical single doses of PGI2 of 4 to 80/micrograms on conjunctiva and cornea of the eye had no effect.