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Updated: May 5, 2026

Using a Chemical Biopsy for Graft Quality Assessment
Published on: June 17, 2020
Perspective: metabolomics has the potential to change the landscape of kidney transplantation diagnostics
Dirk R J Kuypers1,2, Jurre J Kamphorst3, Henriette de Loor1
1Department of Nephrology & Renal Transplantation, University Hospitals Leuven, Belgium.
Abstract:
Kidney transplantation is the most efficient renal replacement therapy. Current diagnostics for monitoring graft health are either invasive or lack precision. Metabolomics is an emerging discipline focused on the analysis of the small molecules involved in metabolism. Given the kidneys' central role in metabolic homeostasis and previous observations of altered metabolites correlating with restricted kidney graft function, metabolomics is highly promising for the discovery of novel biomarkers and the development of novel diagnostics. In this perspective, we summarize the known metabolic roles for the kidney, discuss biomarkers of graft health and immune status emerging from metabolomics research, and provide our perspective on how these and future findings can be integrated in clinical practice to enable precision diagnostics.
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