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Updated: Jun 14, 2025
Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
Published on: February 9, 2024
Enhancing Sensitivity in Nucleic Acid Detection via Collaborative Multiple Catalytic Cores in DNAzyme Nanomachines
Zain Hussein1, Lidia A Golovina1, Meera Alaji1
1Laboratory of Nucleic Acid Nanotechnology, SCAMT Institute, ITMO University, 9 Lomonosova Str., 191002, St. Petersburg, Russian Federation.
Abstract:
We introduce a multicore DNA nanomachine (MDNM), utilizing four binary DNAzymes for nucleic acid detection without the need for a preamplification step. This innovation remarkably yields a reduction in limit of detection (LOD), over 5-fold, as compared to single-core systems. This reduces the required test time thus highlighting the potential of MDNM in advancing nucleic acid detection.
