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Epidemiological Survey of Enterovirus Infections in Taiwan From 2011 to 2020: Retrospective Study

Fang-Chen Liu1, Bao-Chung Chen1, Yao-Ching Huang2

  • 1Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.

JMIR Public Health and Surveillance
|September 5, 2024
PubMed

Insights

Enterovirus (EV) infections are common in young children. This study analyzed EV strains and epidemiology in Taiwan from 2011-2020, finding Coxsackie A virus (CVA) was dominant, with specific strains and clusters linked to certain years and institutions.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Young children are particularly vulnerable to enterovirus (EV) infections, which can lead to significant illness.
  • Understanding the epidemiology and circulating strains of EVs is crucial for managing pediatric health.

Purpose of the Study:

  • To investigate the characteristics of enterovirus strains and their epidemiology among young children in Taiwan.
  • To analyze epidemic patterns, sporadic and cluster cases, and identify key institutions involved in EV infections from 2011 to 2020.

Main Methods:

  • Utilized national surveillance data from Taiwan Centers for Disease and Control (2011-2020).
  • Analyzed outpatient and emergency department visits for EV infections.
  • Identified and characterized EV strains using immunofluorescence assays and analyzed cluster data.

Main Results:

  • Coxsackie A virus (CVA) was the dominant EV type (68.9%), with CVA10, CVA2, CVA6, CVA4, and CVA16 being most frequent.
  • Significant yearly variations in EV strain prevalence were observed, with specific years showing increased odds for EV-A71, CVA, echovirus, and CVB.
  • 57 EV clusters were reported, predominantly CVA (93%), with CVA6 and CVA10 as major causes. Populous institutions reported the most clusters.

Conclusions:

  • This study provides the first comprehensive report on sporadic and cluster EV infections in Taiwan using national surveillance data (2011-2020).
  • Findings offer valuable insights for policymakers and clinicians to target prevention and control strategies for severe EV infections and their burden in Taiwan.
Abstract

Keywords:
Taiwanclusterdomesticenterovirusepidemiologyretrospectivesporadic

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