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Methods for Detecting Cough and Airway Inflammation in Mice
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Current opinion in refractory and/or unexplained chronic cough.

Stephanie Misono1, Carolyn K Novaleski2

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Minnesota School of Medicine, Minneapolis, Minnesota.

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Summary

Otolaryngologists play a key role in managing adult chronic cough. New research highlights its complexity, psychosocial impacts, and personalized treatment strategies, including novel therapies.

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Area of Science:

  • Otolaryngology
  • Neurology
  • Pulmonology

Background:

  • Chronic cough in adults is a complex condition with significant psychosocial impacts.
  • Recent research is elucidating the neural mechanisms of cough in both peripheral and central nervous systems.
  • Otolaryngologists are essential for effective chronic cough management.

Purpose of the Study:

  • To present updates on rapidly evolving concepts in chronic cough.
  • To highlight advancements in understanding the neural basis of cough.
  • To discuss emerging personalized treatment approaches for chronic cough.

Main Methods:

  • Review of recent scientific literature and clinical practice recommendations.
  • Analysis of ongoing investigations into chronic cough subgroups.
  • Characterization of clinical outcome measures for chronic cough.

Main Results:

  • Evidence of major psychosocial impacts of chronic cough is strengthening.
  • The complexity of cough, involving peripheral and central neural pathways, is increasingly recognized.
  • Personalized treatment strategies addressing "treatable traits" are emphasized in recent guidelines.

Conclusions:

  • Otolaryngologists should raise awareness of the larynx's role in cough.
  • Multidisciplinary collaboration is crucial for advancing chronic cough care.
  • Future developments include more pharmacologic options and personalized treatment approaches for chronic cough.