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Quantitative Spermidine Detection in Cosmetics using an Organic Transistor-Based Chemical Sensor.

Yui Sasaki^1,2, Kohei Ohshiro¹, Miyuki Kato¹

¹Institute of Industrial Science, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, 153-8505 Tokyo, Japan.

|September 5, 2024

Summary

A new organic field-effect transistor (OFET) chemical sensor quantifies spermidine, an antiaging biomarker, in cosmetics. This innovative tool offers easy, direct analysis without sample purification, advancing cosmetic science.

Keywords:

Amines Cosmetic analysis Organic transistor Sensors

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Area of Science:

Biomarker detection
Chemical sensing
Materials science

Background:

Spermidine is a crucial antiaging biomarker with high demand for detection in life sciences.
Existing analytical tools for spermidine often require complex sample purification, limiting their practical application.
Development of user-friendly sensors for direct spermidine quantification is needed.

Purpose of the Study:

To develop and validate an organic field-effect transistor (OFET)-based chemical sensor for quantifying spermidine concentration in commercial cosmetics.
To establish a direct, sample-purification-free method for spermidine detection in cosmetic products.
To demonstrate the sensor's feasibility and reliability for cosmetic ingredient analysis.

Main Methods:

Utilized an extended-gate structure for the OFET-based chemical sensor to enable sensing in aqueous media.
Integrated a coordination-bond-based sensing system into the OFET device to translate spermidine detection into measurable changes in transistor characteristics.
Employed high-performance liquid chromatography (HPLC) for instrumental validation of the OFET sensor's performance.

Main Results:

The extended-gate OFET sensor demonstrated quantitative responses to spermidine, achieving a limit of detection of 2.3 μM.
The sensor's detectability is sufficient for quantifying spermidine levels typically found in commercial cosmetics.
Validation using HPLC showed high recovery rates (108-111%) for spermidine in cosmetic ingredient products.

Conclusions:

The developed OFET-based chemical sensor provides a viable, user-friendly method for direct spermidine quantification in cosmetics.
The sensor's ability to detect spermidine without sample purification significantly simplifies the analytical process.
The findings support the feasibility of using this OFET-based sensor for routine cosmetic analysis and quality control.