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Published on: June 14, 2019
Human Papillomavirus Vaccination and Human Papillomavirus-Related Cancer Rates
Victor Adekanmbi1,2, Itunu Sokale3,4, Fangjian Guo1,2
1Center for Interdisciplinary Research in Women's Health, School of Medicine, The University of Texas Medical Branch, Galveston.
Targeted interventions are needed in Texas to increase human papillomavirus (HPV) vaccination rates, particularly in North Texas regions with lower vaccination coverage and higher HPV-related cancer incidence. This strategy aims to reduce the future burden of these cancers.
Area of Science:
- Public Health
- Epidemiology
- Vaccinology
Background:
- Human papillomavirus (HPV) related cancers pose a significant public health challenge.
- Understanding geographic variations in HPV vaccination and cancer incidence is crucial for effective intervention design in Texas.
Purpose of the Study:
- To evaluate temporal trends and geospatial patterns of HPV vaccination initiation and completion rates.
- To analyze HPV-related cancer incidence rates at county and health service region (HSR) levels in Texas.
Main Methods:
- Population-based, cross-sectional study utilizing Texas Immunization Registry and SEER data (2006-2022).
- Analysis of HPV vaccination rates in individuals aged 9-17 years.
- Analysis of HPV-related cancer incidence rates in individuals aged 20 years and older.
Main Results:
- Significant variation in HPV vaccination initiation (6.3%-77.6%) and up-to-date rates (1.6%-34.8%) observed across Texas counties.
- HPV-related cancer incidence rates ranged from 0 to 154.2 per 100,000 for females and 0 to 60.1 per 100,000 for males.
- North Texas (HSRs 2/3 and 4/5N) exhibited lower HPV vaccination rates and higher cancer incidence.
Conclusions:
- Geographic disparities in HPV vaccination coverage and HPV-related cancer incidence exist within Texas.
- Targeted interventions focusing on increasing HPV vaccination uptake and completion in low-coverage areas are recommended.
- Addressing these disparities can help mitigate the future burden of HPV-related cancers.
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