Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[HLA antigens in lung diseases].

A G Khomenko, L E Pospelov, A F Malenko

    Terapevticheskii Arkhiv
    |January 1, 1985
    PubMed
    Summary

    Human Leukocyte Antigen (HLA) genes significantly influence susceptibility to pulmonary diseases like tuberculosis, sarcoidosis, and allergic alveolitis, with specific HLA genes linked to each condition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Impaired pulmonary function and ineffective endobronchial valve placement in patients with TB.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2026
    Same author

    Development of a Test System to Detect the Omicron Variant of SARS-CoV-2 and the Frequency of Its Detection in Patients.

    Bulletin of experimental biology and medicine·2022
    Same author

    Interference of phase-shifted chirped laser pulses for secure free-space optical communications.

    Applied optics·2018
    Same author

    Controlled nanostructures formation on stainless steel by short laser pulses for products protection against falsification.

    Optics express·2018
    Same author

    [Increased serum concentrations of inflammatory cytokines in type 2 diabetic patients with chronic kidney disease].

    Terapevticheskii arkhiv·2015
    Same author

    [The medical and sanitary passport of chemically hazardous facility and the surrounding area as the register of indicators of sanitary and epidemiologic safety of a state of health and habitat areas].

    Gigiena i sanitariia·2013

    Area of Science:

    • Immunogenetics
    • Pulmonology
    • Human Genetics

    Background:

    • Genetic factors, particularly Human Leukocyte Antigen (HLA) genes, are implicated in the susceptibility to various pulmonary diseases.
    • Understanding these genetic associations can provide insights into disease pathogenesis and potential therapeutic targets.

    Purpose of the Study:

    • To investigate the role of HLA genes in the susceptibility to tuberculosis, sarcoidosis, and exogenous allergic alveolitis.
    • To identify specific HLA alleles associated with increased risk for these pulmonary conditions.

    Main Methods:

    • Case-control study involving patients with tuberculosis, sarcoidosis, exogenous allergic alveolitis, chronic bronchitis, and healthy controls.
    • Analysis of Human Leukocyte Antigen (HLA) gene associations with different pulmonary diseases.

    Main Results:

    • Significant associations were found between specific HLA genes and susceptibility to tuberculosis (HLA-B14), sarcoidosis (HLA-B7), and exogenous allergic alveolitis (HLA-B8).
    • Polygenic control of pulmonary disease susceptibility is suggested, with HLA-B14 and HLA-B15 playing roles in tuberculosis resistance.
    • HLA-B15 may be associated with the development of disseminated, chronic, and disintegrative tuberculosis due to lower resistance.

    Conclusions:

    • HLA genes are crucial determinants of susceptibility to specific pulmonary diseases.
    • Different HLA alleles confer varying levels of hypersusceptibility to distinct pulmonary conditions.
    • While HLA genes are important, other genetic systems likely also contribute to the complex susceptibility profile of tuberculosis.

    Related Experiment Videos