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Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

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Updated: Jun 14, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Microbubble-Enhanced Transdermal Drug Delivery Sonoelectric Patch.

Xinyue Zhang¹, Yihe Zhang¹, Yao Chen¹

¹Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources, Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing 100083, People's Republic of China.

ACS Applied Materials & Interfaces

|September 5, 2024

Summary

This summary is machine-generated.

This study introduces an innovative transdermal drug delivery patch that uses ultrasound energy to generate electricity, significantly boosting drug penetration. This novel approach enhances drug blood concentrations by over 100% compared to traditional methods.

Keywords:

drug penetration pain management therapeutic effects transdermal patch ultrasound energy

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Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

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Published on: June 12, 2021

Area of Science:

Biomedical Engineering
Materials Science
Pharmacology

Background:

Transdermal drug delivery offers convenience but often suffers from low efficiency due to reliance on passive diffusion.
Ultrasound-enhanced transdermal delivery shows promise but is limited by inefficient energy utilization within the patch.
Existing methods lack sufficient drug penetration and require optimization for effective therapeutic outcomes.

Purpose of the Study:

To develop a novel transdermal patch for enhanced drug delivery.
To improve ultrasound energy conversion and utilization for transdermal drug transport.
To investigate the combined effects of ultrasound, electric fields, and drug properties on delivery efficacy.

Main Methods:

Development of a transdermal patch incorporating microsized air pockets and a piezoelectric soft structure.
Integration of ultrasound energy conversion into electrical energy within the patch.
Evaluation of drug delivery efficacy using a pain-release model in animal experiments.

Main Results:

The patch effectively converts ultrasound energy into electrical energy, enhancing drug flow.
Synergistic action of ultrasound pressure and electric fields significantly improves transdermal delivery.
Animal studies showed a 100% increase in drug blood concentrations compared to ultrasound-only delivery.

Conclusions:

The developed transdermal patch demonstrates superior drug delivery efficacy compared to existing methods.
Delivery performance is tunable based on ultrasound power, air pocket size, and drug characteristics.
The patch maintains safe operating temperatures and uses thermochromic changes for effective ultrasound-patch matching.