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Recent advances with erythrocytes as therapeutics carriers
Reyhaneh Hadi Barhaghtalab1, Hammed Tanimowo Aiyelabegan2, Hassan Maleki3
1Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
International Journal of Pharmaceutics
|September 5, 2024
Summary
Erythrocytes, or red blood cells, are promising natural drug delivery systems due to their biocompatibility and long circulation. This review explores their potential for targeted therapies and diagnostics.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Pharmacology
Background:
- Erythrocytes (red blood cells) are increasingly recognized for their potential in drug delivery.
- Their inherent properties like biocompatibility and biodegradability offer advantages over synthetic carriers.
- Understanding erythrocyte structure is key to optimizing their function as drug carriers.
Purpose of the Study:
- To provide a comprehensive overview of erythrocyte structure and properties relevant to drug delivery.
- To discuss advancements in erythrocyte-based nanocarriers for targeted therapies.
- To explore current and potential in vivo and in vitro applications of erythrocytes in medicine and diagnostics.
Main Methods:
- Review of existing literature on erythrocyte structure and function.
- Analysis of current research on erythrocyte-based nanocarrier development.
- Discussion of in vivo and in vitro studies utilizing erythrocytes for drug delivery and diagnostics.
Main Results:
- Erythrocytes possess favorable characteristics for drug delivery, including long circulation times.
- Erythrocyte-based nanocarriers show potential for active and passive targeting of specific tissues, including cancer and the reticuloendothelial system (RES).
- Recent discoveries highlight diverse medicinal and diagnostic applications.
Conclusions:
- Erythrocytes are versatile and biocompatible carriers with significant potential in drug delivery.
- Further research into erythrocyte-based systems can enhance therapeutic efficacy and diagnostic capabilities.
- Clinical relevance of erythrocyte carriers is being increasingly recognized for managing various disorders.
Keywords:
Active targetingDrug deliveryErythrocytesMechanical targetingNanorythrosomesPassive targetingMore Related Videos
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