xiVIEW: Visualisation of Crosslinking Mass Spectrometry Data

Area of Science:

• Biochemistry
• Structural Biology
• Bioinformatics

Background:

• Crosslinking mass spectrometry (MS) is crucial for determining protein complex structures and interaction networks.
• A lack of integrated visualization tools hinders the use of crosslinking MS data for biological insights.

Purpose of the Study:

• To develop xiVIEW, a web-based application for streamlined crosslinking MS data analysis.
• To provide a user-friendly platform integrating diverse data types for biological investigation.

Main Methods:

• Development of a web-based application, xiVIEW.
• Integration of mass spectrometric data, network visualization, UniProtKB annotations, and 3D structures.
• Implementation of a standards-compliant parser for improved data integration.

Main Results:

• xiVIEW offers a user-friendly interface for coordinated data views.
• The tool supports accessible visualization of crosslinking MS data.
• xiVIEW promotes standard file formats for enhanced data integration.

Conclusions:

• xiVIEW empowers researchers to analyze crosslinking MS data more effectively.
• The application facilitates deeper investigations into complex biological systems.
• xiVIEW is expected to advance crosslinking MS-inspired research.