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The scaffolding function of LSD1 controls DNA methylation in mouse ESCs.

Sandhya Malla1,2, Kanchan Kumari1,2, Carlos A García-Prieto3,4

  • 1Department of Molecular Biology, Umeå University, Umeå, Sweden.

Nature Communications
|September 5, 2024
PubMed
Summary

Lysine-specific histone demethylase 1 (LSD1) is crucial for mouse embryonic stem cell (ESC) growth and differentiation, but not self-renewal. LSD1 controls DNA methylation stability independently of its demethylase activity.

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