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Updated: Jun 14, 2025

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

Stem cell-based approaches for developmental neurotoxicity testing.

Joy Ku¹, Prashanth Asuri¹

¹Department of Bioengineering, Santa Clara University, Santa Clara, CA, United States.

Frontiers in Toxicology

|September 6, 2024

Summary

This summary is machine-generated.

This review explores stem cell-based methods for testing neurotoxicants, focusing on developmental neurotoxicants (DNTs). It highlights advancements and future directions, including in silico approaches, for more accurate toxicity assessments.

Keywords:

developmental neurotoxicity (DNT)integrated approaches for testing and assessment (IATA)neural stem cell (NSC)new approach methodologies (NAM)predictive modeling

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Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Published on: June 9, 2017

Area of Science:

Neuroscience
Toxicology
Biotechnology

Background:

Neurotoxicants pose risks to nervous system structure and function.
Current animal models for neurotoxicity testing have limitations.
Stem cell-based platforms offer a promising alternative for accurate assessment.

Purpose of the Study:

To review current technologies and advancements in evaluating neurotoxicants using stem cell-based approaches.
To emphasize developmental neurotoxicants (DNTs) due to their potential for irreversible damage.
To discuss future applications of in silico methods in neurotoxicity testing.

Main Methods:

Review of stem cell-based platforms for neurotoxicity evaluation.
Focus on developmental neurotoxicity (DNT) assessment.
Exploration of predictive model approaches for neural cell fate and DNT.

Main Results:

Stem cell platforms provide a biologically accurate alternative to animal models.
Advancements in predictive modeling enhance DNT studies.
In silico methods are emerging as valuable tools in neurotoxicity testing.

Conclusions:

Stem cell-based approaches are advancing neurotoxicity testing.
Developmental neurotoxicants require rigorous evaluation using novel methods.
Integration of in silico tools and regulatory support will shape future neurotoxicity assessments.