Alteration of pituitary-thyroid function in patients with chronic renal failure treated by haemodialysis or...

Pituitary-thyroid function was investigated in 60 patients with chronic renal failure and 18 normal subjects. Serum triiodothyronine and free thyroxine levels were lower in patients treated by either haemodialysis or continuous ambulatory peritoneal dialysis compared with the normal subjects. Serum thyroxine and free thyroxine index were significantly lower in the haemodialysis-treated patients than in the normal subjects. There were no differences in serum thyroxine and free thyroxine index between the continuous ambulatory peritoneal dialysis-treated and normal groups. Serum thyrotrophin was not raised in any of the groups but the serum thyrotrophin response to thyrotrophin-releasing hormone was blunted in both groups of patients. Basal serum prolactin and growth hormone were raised in both groups of patients but there was no significant difference between them. This study confirmed that pituitary-thyroid function is abnormal in patients receiving haemodialysis and established that a similar pattern of abnormalities occurs in patients undergoing continuous ambulatory peritoneal dialysis.