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Updated: Jun 14, 2025

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

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Published on: June 5, 2020

Profiling Metal-Induced Genotoxic Endpoints.

Mohammad Shoeb¹, Gregory M Zarus¹, Henry E Abadin¹

¹Office of Innovation and Analytics, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention.

Journal of Environmental Health

|September 6, 2024

Summary

This summary is machine-generated.

Toxic metals like chromium and arsenic can cause DNA damage, leading to genetic alterations. This review summarizes evidence linking metal exposure to genotoxicity and epigenetic changes.

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High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC

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Published on: May 10, 2016

Area of Science:

Environmental Toxicology
Genetics
Epigenetics

Background:

Toxic metals are implicated in DNA damage initiation and progression.
Metal exposure can activate DNA damage response pathways.
Genotoxic endpoints and epigenetic modifications are influenced by metal exposure.

Purpose of the Study:

To systematically review evidence on metal-induced genotoxicity.
To summarize findings from Agency for Toxic Substances and Disease Registry (ATSDR) profiles and literature.
To explore the link between metal exposure and DNA alterations.

Main Methods:

Systematic literature review.
Analysis of ATSDR toxicological profiles.
Inclusion of studies on specific metals: chromium, arsenic, nickel, lead, mercury, and zinc.

Main Results:

Accumulating evidence suggests a link between metal exposure and genotoxic endpoints.
Metal exposure can induce global and gene-specific DNA alterations.
Epigenetic modifications are also influenced by toxic metal exposure.

Conclusions:

Toxic metals contribute to DNA damage and genotoxicity.
Further research is warranted to fully understand metal-induced genetic and epigenetic effects.
Public health awareness regarding metal exposure risks is crucial.