Cardiovascular Disease After Hematopoietic Stem Cell Transplantation in Adults: JACC: CardioOncology State-of-the-Art...

Area of Science:

• Cardiology
• Hematology
• Oncology

Background:

• Hematopoietic cell transplantation (HCT) use has grown, now including older and more comorbid patients.
• These patients experience a higher incidence of cardiovascular disease post-transplant.
• Therapeutic agents used in HCT can possess cardiotoxic properties.

Purpose of the Study:

• To review the cardiotoxicity associated with hematopoietic cell transplantation (HCT).
• To outline a risk assessment strategy for cardiovascular complications after HCT.
• To describe an approach for ongoing cardiovascular care in HCT patients.

Main Methods:

• Comprehensive literature review on HCT and cardiovascular complications.
• Analysis of risk factors influencing cardiotoxicity post-HCT.
• Synthesis of current guidelines for cardiovascular assessment and surveillance.

Main Results:

• Cardiovascular complications include arrhythmias, heart failure, myocardial infarction, and pericardial effusions.
• Risk stratification depends on transplant type (autologous vs. allogeneic) and patient comorbidities.
• Proactive cardiovascular assessment before HCT is crucial.

Conclusions:

• Cardiovascular disease is a significant concern following HCT, particularly in expanded patient populations.
• Tailored cardiovascular surveillance and risk management are essential for improving outcomes.
• Early identification and management of cardiotoxicity can mitigate adverse events.