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Behind the screen: drug discovery using the big data of phenotypic analysis
Merrill M Froney1, Michael B Jarstfer1, Samantha G Pattenden1
1Department of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Frontiers in Education
|September 6, 2024
Summary
This case study introduces phenotypic screening for drug discovery, using big data to identify disease inhibitors. It enhances student confidence in discussing drug discovery topics and applying statistical methods.
Area of Science:
- Biochemistry
- Pharmacology
- Computational Biology
Background:
- Keeping pace with technological advances in drug discovery is challenging for educators.
- The High-throughput Discovery Science and Inquiry-based Case Studies for Today's Students (HITS) network aims to bridge this gap.
- Phenotypic screening is crucial for identifying drug candidates for diseases with unknown cellular targets.
Purpose of the Study:
- To introduce students and faculty to phenotypic screening using big data analysis.
- To provide a pedagogical tool for teaching current drug discovery methods.
- To enhance student understanding of identifying and analyzing hit compounds.
Main Methods:
- Developed a case study titled "Behind the Screen: Drug Discovery using the Big Data of Phenotypic Analysis."
- Utilized datasets modeled on real phenotypic screening methods.
- Incorporated statistical procedures relevant to drug discovery research.
Main Results:
- The case study was tested on 70 students across three universities and various courses.
- Students learned to identify hit compounds and understand the biological significance of their findings.
- Survey data showed a significant increase in student confidence and ability to discuss key topics.
Conclusions:
- The "Behind the Screen" case study effectively teaches phenotypic screening and big data analysis in drug discovery.
- This pedagogical tool is adaptable for both undergraduate and graduate levels.
- The approach successfully improved student attitudes and confidence in drug discovery concepts.
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