Related Experiment Video
Updated: Jun 28, 2026

08:07
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
7.2K
Osteosarcoma of Mandible - A Case Report.
Vinitha G Kaimal1, Anuradha Pai1
1Department of Oral Medicine and Radiology, The Oxford Dental College, Bommanahalli, 560068 Bangalore India.
Indian Journal of Surgical Oncology
|September 6, 2024
Summary
Osteosarcoma, a rare malignant bone tumor, can occur in the jaw. Early clinical and radiographic diagnosis is crucial due to its aggressive nature and rapid progression.
Area of Science:
- Oncology
- Oral and Maxillofacial Surgery
- Pathology
Background:
- Osteosarcoma is the second most common primary bone tumor, representing 20% of all sarcomas.
- While long bones are common sites, jaw bone involvement occurs in approximately 5% of cases, with an incidence of 1 in 1.5 million.
- This malignancy is characterized by the formation of bone or osteoid by tumor cells.
More Related Videos
Related Concept Videos
Bone Structure
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

