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Different care mode alter composition and function of gut microbiota in cerebral palsy children

Jinli Lyu1, Xiaowei Zhang1, Shenghua Xiong2

  • 1Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.

Frontiers in Pediatrics
|September 6, 2024
PubMed

Insights

Family-centered care positively impacts the gut microbiota in children with cerebral palsy (CP). This care mode promotes beneficial bacteria and metabolic functions, crucial for CP recovery and intervention development.

Area of Science:

  • Microbiome research
  • Pediatric gastroenterology
  • Cerebral palsy (CP) research

Background:

  • Specialized care is vital for children with cerebral palsy (CP) recovery.
  • The gut microbiota plays a significant role in overall health and disease.

Purpose of the Study:

  • To investigate the impact of different care modes on the gut microbiota composition and function in children with CP.
  • To compare the gut microbiota profiles of children with CP cared for by family versus those in welfare institutions.

Main Methods:

  • Fecal samples were collected from 32 children with CP.
  • Children were divided into a family-centered care group (n=21) and an institutional care group (n=11).
  • Gut microbiota profiles were analyzed using sequencing.

Main Results:

  • No significant differences in alpha-diversity or phylum-level abundance were observed.
  • Family care increased beneficial butyrate-producing bacteria (Bacteroides, Lachnospiracea incertae sedis) and decreased opportunistic pathogens (Prevotella, Clostridium, Oscillibacter, Fusobacterium) at the genus level.
  • Metabolic pathways, including lipid and carbohydrate metabolism, were upregulated in the family-centered care group and positively correlated with beneficial bacteria.

Conclusions:

  • Family-centered care positively influences the gut microbiota composition and function in children with CP.
  • Findings suggest that care environment significantly impacts the gut microbiome, offering potential therapeutic targets for CP management.
Abstract

Keywords:
16S rRNA sequenceGut microbiotacerebral palsyfamily-centered care modewelfare-centered care mode

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