Research progress on the natural products in the intervention of myocardial infarction

Area of Science:

• Cardiology
• Pharmacology
• Natural Products Research

Background:

• Coronary heart disease, particularly myocardial infarction (MI), is a growing global health concern with increasing incidence in younger populations.
• Current clinical treatments for MI, including thrombolysis and revascularization, have limitations and can lead to poor prognoses.
• Research limitations in synthetic drugs are driving interest towards natural substances for novel therapeutic strategies.

Purpose of the Study:

• To investigate the molecular mechanisms underlying myocardial infarction (MI).
• To evaluate the therapeutic potential and application of natural products and medicinal plants in MI treatment over the last five years.
• To highlight the safety and efficacy of natural therapies in managing MI.

Main Methods:

• Review of scientific literature focusing on natural products and medicinal plants for MI treatment.
• Analysis of studies published within the past five years.
• Investigation of molecular mechanisms, including oxidative stress, inflammation, apoptosis, and others.

Main Results:

• Natural products demonstrate significant therapeutic potential and superior tolerance for MI management.
• These natural therapies mitigate myocardial cell damage through diverse mechanisms.
• Identified pathways include oxidative stress, inflammation, apoptosis, angiogenesis, fibrosis, autophagy, ER stress, mitophagy, and pyroptosis.

Conclusions:

• Natural medicines represent a novel, safer, and more effective approach to MI treatment.
• Targeting multiple pathogenic pathways with natural products offers a comprehensive strategy for MI management.
• This review provides current insights into natural product-based MI therapies, aiding in prevention and treatment strategies.