Bone scaffolds-based localized drugs delivery for osteosarcoma: current status and future perspective.

Area of Science:

• Oncology
• Biomaterials Science
• Drug Delivery Systems

Background:

• Osteosarcoma is a prevalent malignant bone neoplasm in adolescents.
• Standard treatment involves chemotherapy, surgery, and radiation therapy.
• Surgical resection often results in incomplete tumor eradication, leading to recurrence, metastasis, and high mortality rates.

Purpose of the Study:

• To review current bone scaffold technologies for drug delivery in osteosarcoma treatment.
• To highlight studies utilizing scaffolds as drug delivery systems (DDSs) for osteosarcoma.
• To discuss challenges and future perspectives of scaffold-based DDSs in osteosarcoma management.

Main Methods:

• Literature review of bone scaffolds and their application as DDSs.
• Analysis of studies focusing on scaffold-based treatment for osteosarcoma.
• Discussion of existing challenges and future directions in the field.

Main Results:

• Bone scaffolds can be engineered as DDSs to deliver therapeutic agents postoperatively.
• Various bone scaffold types are available for potential use in osteosarcoma treatment.
• Scaffold-based DDSs show potential for improving postoperative management and reducing recurrence.

Conclusions:

• Scaffold-based DDSs represent a viable strategy for enhancing osteosarcoma treatment outcomes.
• Further research is needed to overcome challenges and optimize the use of these systems.
• This review provides insights for developing effective and safe postoperative osteosarcoma treatment plans.