Related Experiment Video

Updated: Jun 14, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

402

Implication of IL-12A, IL-12B, IL-6, and TNF single-nucleotide polymorphisms in severity and susceptibility to

R Benmansour1, M R Tagajdid1, I A Lahlou1

  • 1Center of Virology, Infectious and Tropical Diseases, Mohamed V Military Teaching Hospital, University Mohammed V in Rabat, Rabat, Morocco.

International Journal of Immunopathology and Pharmacology
|September 6, 2024
PubMed

Insights

Genetic factors influencing COVID-19 outcomes were studied. While most gene polymorphisms showed no link to COVID-19 severity, a specific Interleukin-6 (IL-6) variant suggested a protective effect against SARS-CoV-2 infection.

Area of Science:

  • Immunogenetics
  • Genomics
  • Infectious Disease Epidemiology

Background:

  • The COVID-19 pandemic caused significant global health issues.
  • Understanding genetic influences on disease severity is crucial for pathogenesis insights and therapeutic strategies.

Purpose of the Study:

  • To investigate the association between single nucleotide polymorphisms (SNPs) in IL-12A, IL-12B, IL-6, and TNF genes and COVID-19 severity and susceptibility in Moroccan patients.

Main Methods:

  • Next-Generation Sequencing (NGS) was performed on 325 Moroccan participants (207 COVID-19 patients, 118 controls).
  • Statistical analysis utilized logistic regression models to assess correlations with disease severity and susceptibility.

Main Results:

  • No significant association was found between SNPs in IL-12A, IL-12B, IL-6, or TNF and overall COVID-19 severity or susceptibility.
  • A specific IL-6 SNP (rs2069840) showed a negative correlation, indicating a potential protective effect against SARS-CoV-2 infection.

Conclusions:

  • Polymorphisms in IL-12A, IL-12B, IL-6, and TNF genes do not appear to be correlated with COVID-19 severity or susceptibility.
  • The rs2069840 polymorphism in IL-6 may offer a protective effect against SARS-CoV-2 infection, warranting further investigation.
Abstract

Keywords:
COVID-19IL-12AIL-12BIL-6NGSTNFhost genetics

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.2K

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
14.9K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
963
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.7K