Human TCR repertoire in cancer
Lin Chen1,2, Yuan Hu2,3, Bohao Zheng2,4,5
1Department of Medical Genetics/Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Chengdu, China.
Cancer Medicine
|September 6, 2024
Summary
T-cell receptor (TCR) repertoire analysis reveals crucial insights into cancer immunity. Next-generation sequencing (NGS) enhances understanding of TCR diversity for cancer diagnosis and treatment monitoring.
Area of Science:
- Immunology
- Oncology
- Genomics
Background:
- T cells are vital for antitumor immunity, with T-cell receptors (TCRs) enabling antigen identification.
- TCR repertoire diversity is generated through unique rearrangement mechanisms, essential for specific antigen recognition.
- A healthy TCR repertoire is critical for effective T-cell function in immune responses.
Purpose of the Study:
- To systematically review TCR generation mechanisms and analysis methods.
- To highlight the application of next-generation sequencing (NGS) in TCR repertoire analysis.
- To explore the role of TCR repertoires in cancer immunity, progression, and treatment.
Main Methods:
- Systematic review of TCR creation and analysis methodologies.
- Focus on next-generation sequencing (NGS) applications.
- Exploration of TCR repertoire in health and cancer contexts.
Main Results:
- TCR repertoire analysis shows potential for monitoring cancer development and progression.
- It aids in assessing treatment response and patient prognosis.
- NGS has significantly advanced the understanding of TCR diversity in cancer immunity.
Conclusions:
- Further research is needed to validate TCR repertoires as biomarkers.
- TCR repertoire analysis using advanced sequencing is a promising future tool.
- This analysis will be crucial for cancer diagnosis, monitoring, and therapy evaluation.
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