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Lautropia mirabilis sepsis in immunodeficiency: first report and genomic features
Svea Genseke1, Mirjeta Berisha2, Aljoscha Teerstegen1
1Medical Faculty, Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Purpose:
Lautropia mirabilis is a Gram-negative, facultative anaerobic coccus, which has been detected mainly in respiratory sites of immunodeficient patients suffering from HIV or cystic fibrosis. To date, knowledge about the pathogenicity of L. mirabilis is spare due to the small numbers of documented cases.
Methods:
We present a literature review and report the case of a 39-year-old female diagnosed with common variable immunodeficiency (CVID) with IgG and IgA deficiency suffering from a sepsis with L. mirabilis. As no fully closed L. mirabilis genome besides the type strain was available to date, we additionally performed complete genome sequencing of L. mirabilis.
Results:
The patient was admitted to our hospital with recurrent episodes of fever. Here, we detected L. mirabilis in two different blood cultures. The bacterium was tested susceptible to and treated with meropenem. As the origin of L. mirabilis sepsis, we observed an active periodontitis likely due to impaired IgA levels and mucosal insufficiency as a consequence of CVID. Whole genome sequencing of L. mirabilis revealed several genes important for host cell invasion and intracellular survival of the pathogen.
Conclusions:
Our case highlights the importance of L. mirabilis in immunocompromised patients also in other compartments than the respiratory tract.
Insights
Lautropia mirabilis sepsis was identified in an immunocompromised patient. Whole genome sequencing revealed genes for invasion and survival, highlighting the bacterium
Area of Science:
- Medical Microbiology
- Genomics
- Immunology
Background:
- Lautropia mirabilis is a Gram-negative coccus primarily found in respiratory sites of immunocompromised individuals.
- Limited data exists on L. mirabilis pathogenicity due to infrequent case reports.
Purpose of the Study:
- To investigate the pathogenicity of L. mirabilis in an immunocompromised patient.
- To perform whole genome sequencing of L. mirabilis to identify virulence factors.
Main Methods:
- Literature review and case report of a patient with common variable immunodeficiency (CVID) and L. mirabilis sepsis.
- Complete genome sequencing of the L. mirabilis isolate.
Main Results:
- L. mirabilis was detected in blood cultures of a patient with CVID, treated successfully with meropenem.
- Active periodontitis was identified as the likely source of sepsis, linked to IgA deficiency and mucosal issues.
- Genome sequencing identified genes associated with host cell invasion and intracellular survival.
Conclusions:
- L. mirabilis can cause sepsis in immunocompromised patients beyond respiratory sites.
- This case underscores the clinical significance of L. mirabilis in immunocompromised individuals.
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