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Updated: Jun 14, 2025

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
Published on: September 27, 2013
Controlled Release of Molecules to Enhance Cell Survival and Regeneration
Xin Fan1, Phillip A Harding2, Morgan V DiLeo3,4,5,6
1Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Abstract:
Controlled release or controlled drug delivery comprises the set of techniques and approaches to improve bioavailability through improved safety and/or efficacy using a carrier material for the molecule of interest. The predictability and tunability of these carriers make them ideal for protection, localization, and sustained presentation of a wide range of therapeutics, including growth factors implicated in cell survival and regeneration. Here we provide a method for encapsulating epidermal growth factor in a degradable polymer matrix for delivery to the cornea. Additional notes are included to demonstrate the wide-ranging capabilities of such methods for other materials, therapeutic agents, and sites of action within the eye.
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