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Extracellular volume fraction of liver and pancreas using spectral CT in hypertensive patients: A comparative study
Xiaoming Huang1, Zhen Zhang1, Jiansheng Wang2
1Department of Radiology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Insights
Hypertension increases extracellular volume fraction (ECV) in the liver and pancreas. This imaging marker, especially liver ECV, may help detect chronic organ damage in hypertensive patients.
Area of Science:
- Radiology and Medical Imaging
- Cardiovascular Medicine
- Gastroenterology
Background:
- Hypertension, beyond cardiovascular effects, is linked to chronic damage in organs like the liver and pancreas.
- Imaging techniques may reveal this chronic organ damage in hypertensive individuals.
Purpose of the Study:
- To investigate the relationship between hypertension indicators and extracellular volume fraction (ECV) in the liver and pancreas using iodine maps.
- To assess the clinical utility of ECV measurements for detecting chronic liver and pancreatic damage in hypertension.
Main Methods:
- A prospective study involving 300 abdominal patients undergoing contrast-enhanced spectral CT.
- Calculation of liver and pancreatic ECV from upper abdominal iodine maps.
- Statistical analysis (Kruskal-Wallis, Spearman, regression) to correlate ECV with hypertension severity and indicators.
Main Results:
- Hypertensive patients exhibited significantly higher liver and pancreatic ECV compared to normotensive individuals.
- A positive correlation was observed between hypertension severity and increased ECV.
- Hypertension severity was identified as an independent predictor of elevated ECV.
Conclusions:
- Liver and pancreatic ECV are positively correlated with hypertension indicators.
- ECV measurements show potential as clinical markers for hypertension-related chronic organ damage.
- Liver ECV demonstrated a stronger association with hypertension stages than pancreatic ECV.
Background:
Besides the direct impact on the cardiovascular system, hypertension is closely associated with organ damage in the kidneys, liver, and pancreas. Chronic liver and pancreatic damage in hypertensive patients may be detectable via imaging.
Objective:
To explore the correlation between hypertension-related indicators and extracellular volume fraction (ECV) of liver and pancreas measured by iodine maps, and to evaluate corresponding clinical value in chronic damage of liver and pancreas in hypertensive patients.
Methods:
A prospective study from June to September 2023 included abdominal patients who underwent contrast-enhanced spectral CT. Normal and various grades of hypertensive blood pressure groups were compared. Upper abdominal iodine maps were constructed, and liver and pancreatic ECVs calculated. Kruskal-Wallis and Spearman analyses evaluated ECV differences and correlations with hypertension indicators.
Results:
In 300 patients, hypertensive groups showed significantly higher liver and pancreatic ECV than the normotensive group, with ECV rising alongside hypertension severity. ECVliver displayed a stronger correlation with hypertension stages compared to ECVpancreas. Regression analysis identified hypertension severity as an independent predictor for increased ECV.
Conclusions:
ECVliver and ECVpancreas positively correlates with hypertension indicators and serves as a potential clinical marker for chronic organ damage due to hypertension, with ECVliver being more strongly associated than ECVpancreas.
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