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Updated: Jun 14, 2025
08:39
Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy
Published on: January 7, 2019
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Focal Volume, Acoustic Radiation Force, and Strain in Two-Transducer Regimes.
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
|September 6, 2024
Summary
Orthogonal transducers significantly enhance transcranial ultrasound stimulation (TUS) resolution, enabling precise neural modulation. This breakthrough allows for targeted treatment of deep brain targets with improved safety and efficacy.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Acoustics
Background:
- Transcranial ultrasound stimulation (TUS) is a promising noninvasive technique for neural modulation.
- Deep brain targets are clinically relevant but challenging to access with current TUS due to penetration depth limitations.
Purpose of the Study:
- To develop a TUS method with improved spatial resolution for deep brain targets.
- To investigate the generation of localized acoustic fields and selective pressures using orthogonal transducers.
Main Methods:
- Utilized a pair of 1-MHz orthogonally arranged transducers.
- Analyzed the generation of localized standing waves and acoustic radiation force (ARF).
- Investigated strain arising from particle motion (PM) and ARF.
Main Results:
- Achieved a nearly 40-fold improvement in spatial resolution, targeting subcubic millimeter volumes.
- Demonstrated the generation of highly localized standing waves with periodic compression and tension.
- Showcased the capability to impart selective positive or negative pressures on the target.
Conclusions:
- Orthogonal transducer arrangements significantly enhance TUS spatial resolution and targeting precision.
- This method allows for localized and directed acoustic radiation force (ARF) application.
- Expanded TUS capabilities for investigating ultrasound-neuron interaction mechanisms at finer resolutions.
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