Cognitive function in pituitary adenoma patients: A cross-sectional study.

Area of Science:

• Neuroscience
• Endocrinology
• Psychology

Background:

• Pituitary adenomas can affect cognitive function due to tumor characteristics and hormonal imbalances.
• Transsphenoidal surgery (TSS) is a common treatment, but its long-term cognitive impact requires further investigation.

Purpose of the Study:

• To evaluate cognitive function in patients with pituitary adenoma.
• To identify factors associated with cognitive impairment in this patient group.

Main Methods:

• Cross-sectional study involving 68 patients with pituitary adenoma.
• Cognitive function assessed using the Repeatable Battery for the Assessment of Neuropsychological Status.
• Linear regression analysis used to identify influencing factors.

Main Results:

• Patients with pituitary adenoma demonstrated lower cognitive scores compared to normative data.
• Cognitive variability was significantly associated with sex, educational level, and self-perceived fatigue.
• Pituitary hormone deficiencies, diabetes insipidus, and surgical treatment did not significantly explain cognitive variability.

Conclusions:

• Pituitary adenoma adversely affects cognitive function.
• Sex, education, and fatigue are key factors influencing cognition in these patients.
• Longitudinal studies are recommended for a deeper understanding of cognitive changes.