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Related Experiment Video

Updated: May 5, 2026

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Acoustic Controllable Spatiotemporal Cell Micro-oscillation for Noninvasive Intracellular Drug Delivery.

Xiaoqi Gao^1,2,3, Dayang Li¹, Shukun Zhao^2,3

¹Department of Electronic Engineering, School of Electronic Science and Engineering, Xiamen University, Xiamen 361012, P. R. China.

Analytical Chemistry

|September 6, 2024

Summary

This summary is machine-generated.

Acoustic waves precisely control cell oscillations, enhancing drug delivery efficiency and cell membrane permeability. This gentle method significantly increases intracellular drug concentration without compromising cell viability.

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Area of Science:

Biotechnology
Cellular Mechanics
Nanomedicine

Background:

Efficient intracellular cargo delivery is vital for drug evaluation, nanomedicine, and gene therapy.
Current methods often face challenges in balancing high delivery efficiency with cell viability.

Purpose of the Study:

To develop an acoustic-mediated mechanism for precise intracellular drug delivery.
To enhance cell membrane permeability using controlled cell oscillations.

Main Methods:

Utilized phase shifting keying-based spatiotemporal acoustic tweezers to create controllable oscillating cell arrays.
Applied oscillating radiation force and fluid shear stress to disturb cell membrane mobility and enhance permeability.
Tunable parameters included oscillation frequency, direction, amplitude, and speed.

Main Results:

Achieved active delivery of doxorubicin into cells, resulting in an intracellular concentration over 8 times higher than controls.
Demonstrated excellent biocompatibility with no significant compromise in cell activity.
Showcased tunable cell oscillation from 10⁻² to 10² Hz.

Conclusions:

The proposed
dancing acoustic waves
scheme offers a flexible, gentle, and high-throughput strategy for intracellular cargo delivery.
This method advances cell manipulation in spatial and temporal domains, benefiting nanobiological research and medical treatments.