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Updated: Jun 14, 2025
Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
Published on: December 8, 2023
A second-generation recombinant BCG strain combines protection against murine tuberculosis with an enhanced safety
Ana Maria Valencia-Hernandez1, Guangzu Zhao1, Socorro Miranda-Hernandez1
1Australian Institute of Tropical Health and Medicine, James Cook University, Cairns & Townsville, QLD, Australia.
Abstract:
Bacille Calmette-Guérin (BCG) remains the only licensed vaccine against tuberculosis (TB). While BCG protects against TB in children, its protection against pulmonary TB in adults is suboptimal, and the development of a better TB vaccine is a global health priority. Previously, we reported two recombinant BCG strains effective against murine TB with low virulence and lung pathology in immunocompromised mice and guinea pigs. We have recently combined these two recombinant BCG strains into one novel vaccine candidate (BCGΔBCG1419c::ESAT6-PE25SS) and evaluated its immunogenicity, efficacy and safety profile in mice. This new vaccine candidate is non-inferior to BCG in protection against TB, presents reduced pro-inflammatory immune responses and displays an enhanced safety profile.
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