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Xanthogranulomatous pyelonephritis in childhood.
British Journal of Urology
|June 1, 1985
Summary
Xanthogranulomatous pyelonephritis (XGP) is a rare, unilateral kidney disease affecting children. Early diagnosis is possible by identifying characteristic symptoms like renal calculi and impaired kidney function.
Area of Science:
- Pediatric Nephrology
- Radiology
- Pathology
Background:
- Xanthogranulomatous pyelonephritis (XGP) is an uncommon chronic destructive kidney inflammation.
- It predominantly affects adults but has been reported in children.
Purpose of the Study:
- To report on a series of pediatric cases of XGP.
- To highlight characteristic clinical and radiological findings.
- To suggest the possibility of pre-operative diagnosis.
Main Methods:
- Retrospective case series analysis.
- Review of clinical records, imaging, and pathology reports.
- Correlation of clinical presentation with diagnostic findings.
Main Results:
- Eleven pediatric patients with XGP were identified.
- All cases involved the left kidney, indicating a consistent unilateral presentation.
- Associated findings included renal calculi, significantly impaired renal function, anemia, leukocytosis, and elevated ESR.
- An obstructive element with infection was commonly implicated in the etiology.
Conclusions:
- XGP in children is consistently unilateral.
- Pre-operative diagnosis of XGP is feasible based on characteristic clinical and imaging findings.
- The etiology likely involves obstruction and infection, leading to kidney destruction.