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Preclinical toxicity studies supporting 2DG for treatment of status epilepticus

Thomas P Sutula1, Nathan B Fountain2

  • 1Department of Neurology, University of Wisconsin, Madison WI, USA; Hexokine Therapeutics, Inc. Madison WI, USA.

Epilepsy & Behavior : E&B
|September 6, 2024
PubMed

Keywords:
2-deoxy-D-glucoseEpilepsyGlycolytic inhibitionMetabolism

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Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
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